Reigning Premier League Champions, Manchester City, will face West Ham away on the opening weekend of a 2022-23 campaign that will include a mid-season break for the World Cup in Qatar.
The first fixture takes place on Friday, August 5 when Crystal Palace host Arsenal.
Liverpool play at promoted Fulham, with Nottingham Forest at Newcastle.
Nottingham Forest are back in the Premier League for the first time since 1998-99.
There will be no top-flight games after the weekend of 12-13 November until 26 December because of the World Cup.
The World Cup, which will feature both England and Wales, starts on 21 November. The final is on 18 December, eight days before the Premier League season resumes.
There are no meetings between the Premier League’s so-called ‘big six’ on weekend of November 12 to 13 – the one before the World Cup – following a request by the Football Association.
First round of fixtures in full
Crystal Palace v Arsenal
Bournemouth v Aston Villa
Everton v Chelsea
Fulham v Liverpool
Leeds United v Wolverhampton
Leicester City v Brentford
Newcastle United v Nottingham Forest
Tottenham Hotspur v Southampton
Manchester United v Brighton
West Ham United v Manchester City